Profile

B.S. Nanjing Agricultural University 2011
M.S. Nanjing Agricultural University 2014
Ph.D. Miami University 2018

My research focuses on applying bioinformatics and computational approaches to understand the impacts of environmental exposures on human health. I utilize Omics data, to investigate molecular and cellular responses to various environmental chemicals and toxicants, aiming to identify biomarkers and mechanisms of toxicity. Additional interests include integrating multi-Omics datasets to assess exposure risks and support environmental health protection strategies.

Current research funding

NIEHS/NIH 1 K99/R00 - Improving chemical exposome target prediction by application of Coupled Matrix/Tensor-Matrix/Tensor Completion algorithms

Kai Wang, Minghua Li, Maureen A Sartor, Justin A Colacino, Dana C Dolinoy, Laurie K Svoboda. Perinatal exposure to lead or diethylhexyl phthalate in mice: Sex-specific effects on cardiac DNA methylation and gene expression across time. Environmental Health Perspectives. 2025;133(6): 067014.

Rachel K Morgan†, Kai Wang†, Laurie K Svoboda, Christine A Rygiel, Claudia Lalancette, Raymond Cavalcante, Marisa S Bartolomei, Rexxi Prasasya, Kari Neier, Bambarendage PU Perera, Tamara R Jones, Justin A Colacino, Maureen A Sartor, Dana C Dolinoy. Effects of developmental lead and phthalate exposures on DNA methylation in adult mouse blood, brain, and liver: a focus on genomic imprinting by tissue and sex. Environmental Health Perspectives. 2024;132(6): 067003.

Kai Wang†, Bambarendage PU Perera†, Rachel K Morgan, Kimberley Sala-Hamrick, Viviana Geron, Laurie K Svoboda, Christopher Faulk, Dana C Dolinoy, Maureen A Sartor. piOxi database: a web resource of germline and somatic tissue piRNAs identified by chemical oxidation. Database. 2024;2024: baad096.

Kai Wang, Nicole Kim, Maryam Bagherian, Kai Li, Elysia Chou, Justin A Colacino, Dana C Dolinoy, Maureen A Sartor. Gene Target Prediction of Environmental Chemicals Using Coupled Matrix--Matrix Completion. Environmental science & technology. 2024;58(13): 5889--5898.

Yue Zhao, Xiayan Li, Kai Wang, Gayatri Iyer, Stacey A Sakowski, Lili Zhao, Samuel Teener, Kelly M Bakulski, John F Dou, Bryan J Traynor, Alla Karnovsky, Stuart A Batterman, Eva L Feldman, Maureen A Sartor, Stephen A Goutman. Epigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis. EBioMedicine. 2024;109.

Bambarendage PU Perera†, Kai Wang†, Dongyue Wang, Kathleen Chen, Alisa Dewald, Swati Sriram, Jaclyn M Goodrich, Laurie K Svoboda, Maureen A Sartor, Dana C Dolinoy. Sex and tissue-specificity of piRNA regulation in adult mice following perinatal lead (Pb) exposure. Epigenetics. 2024;19(1): 2426952.

William J Benjamin†, Kai Wang†, Katherine Zarins, Emily Bellile, Freida Blostein, Ilona Argirion, Jeremy MG Taylor, Nisha J DÆSilva, Steven B Chinn, Samara Rifkin, Maureen A Sartor, Laura S Rozek. Oral microbiome community composition in head and neck squamous cell carcinoma. Cancers. 2023;15(9): 2549.

Maryam Bagherian, Elyas Sabeti, Kai Wang, Maureen A Sartor, Zaneta Nikolovska-Coleska, Kayvan Najarian. Machine learning approaches and databases for prediction of drug--target interaction: a survey paper. Briefings in bioinformatics. 2021;22(1): 247--269.

Siyu Liu, Kai Wang, Laurie K Svoboda, Christine A Rygiel, Kari Neier, Tamara R Jones, Raymond G Cavalcante, Justin A Colacino, Dana C Dolinoy, Maureen A Sartor. Perinatal DEHP exposure induces sex-and tissue-specific DNA methylation changes in both juvenile and adult mice. Environmental Epigenetics. 2021;7(1): dvab004.

Christopher Lee, Kai Wang, Tingting Qin, Maureen A Sartor. Testing proximity of genomic regions to transcription start sites and enhancers complements gene set enrichment testing. Frontiers in genetics. 2020;11: 199.

Kai Wang, Siyu Liu, Laurie K Svoboda, Christine A Rygiel, Kari Neier, Tamara R Jones, Justin A Colacino, Dana C Dolinoy, Maureen A Sartor. Tissue-and sex-specific DNA methylation changes in mice perinatally exposed to lead (Pb). Frontiers in genetics. 2020;11: 840.

Bambarendage PU Perera, Zing Tsung-Yeh Tsai, Mathia L Colwell, Tamara R Jones, Jaclyn M Goodrich, Kai Wang, Maureen A Sartor, Christopher Faulk, Dana C Dolinoy. Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA. Epigenetics. 2019;14(5): 504--521.

Kai Wang, Joshua Hoeksema, Chun Liang. piRNN: deep learning algorithm for piRNA prediction. PeerJ. 2018;6: e5429.

Kai Wang, Chun Liang. CRF: detection of CRISPR arrays using random forest. PeerJ. 2017;5: e3219.

Kai Wang, Chun Liang, Jinding Liu, Huamei Xiao, Shuiqing Huang, Jianhua Xu, Fei Li. Prediction of piRNAs using transposon interaction and a support vector machine. BMC bioinformatics. 2014;15(1): 419.