M.Sc. University of Buenos Aires 2002
Ph.D. University of Buenos Aires 2009

I am a lung disease researcher with a combined background in molecular biology, endocrinology, and toxicology. My laboratory studies the cellular and molecular mechanisms underlying sex differences in lung inflammation and lung disease triggered by various environmental exposures. With an interdisciplinary focus on respiratory physiology, molecular endocrinology, and cellular and molecular immunology, we investigate the effects of air pollutants, cigarette smoke, e-cigarettes, and other environmental exposures on the male and female lungs

Current research areas

• Sex differences in lung inflammatory responses to environmental exposures (ambient ozone, particulate matter, allergens, smoking, e-cigarettes, phthalates).
• Effects of the female reproductive cycle in lung inflammatory responses and asthma exacerbations.
• Effects of circulating sex hormones air pollution-induced lung inflammation.
• Mechanisms of estrogen receptor regulation in the context of lung inflammation.
• Sex differences in airway remodeling during asthma and ozone-induced asthma exacerbations.
• Sex differences in the effects of e-cigs and ENDS exposure, including second and third-hand exposures across the life span.
• The effects of environmental exposures, such as endocrine disruptors in the lung's response to allergens and pollutants.
• The interplay of the lung and gut microbiomes in the context of lung health and disease.
• The effects of diet and exercise modifications on lung immunology.

Current research funding

1.R01HL159764 (PI: Silveyra)
Gonadal hormones as mediators of sex and gender influences in asthma

2.R01HL159764-04S1 (PI: Silveyra; Commodore Diversity Supplement)
Gonadal hormones as mediators of sex and gender influences in asthma

3.R01HL159764-04S2 (PI: Silveyra; Borges-Sosa Diversity Supplement)
Sex differences in GPER-mediated mechanisms in allergic asthma

4.P01HL158507 (PI: Gaston; Silveyra Scientific Advisor)
Scientific innovation for personalized severe asthma management

Ekpruke CD, Alford R, Rousselle D, Babayev M, Sharma S, Commodore S, Buechlein A, Rusch DB, Silveyra P. Transcriptomics analysis of allergen-induced inflammatory gene expression in the Four-Core Genotype mouse model. Physiol Genomics. 2023 Dec 4. doi: 10.1152/physiolgenomics.00112.2023.

Commodore S, Ekpruke CD, Rousselle D, Alford R, Babayev M, Sharma S, Buechlein A, Rusch DB, Silveyra P. Lung pro-inflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones. Physiol Genomics. 2023 Dec 4. doi: 10.1152/physiolgenomics.00049.2023.

Alam F, Silveyra P. Sex differences in e-cigarette use and related health effects. Int J Environ Res Public Health. 2023 Nov 18;20(22):7079. doi: 10.3390/ijerph20227079.

Commodore S, Sharma S, Ekpruke CD, Pepin R, Hansen A, Rousselle D, Babayev M, Ndeke JM, Alford R, Parker E, Dickinson S, Sharma S, Silveyra P. Thirdhand vaping exposures are associated with pulmonary and systemic inflammation in a mouse model. J Environ Expo Assess 2023;2:22, doi: 10.20517/jeea.2023.27

Sundar IK, Duraisamy SK, Choudhary I, Saini Y, Silveyra P. Acute and Repeated Ozone Exposures Differentially Affect Circadian Clock Gene Expression in Mice. Adv Biol (Weinh). 2023 Nov;7(11):e2300045. doi: 10.1002/adbi.202300045.

Fuentes N, Nicoleau M, Cabello N, Montes D, Zomorodi N, Chroneos ZC, Silveyra P. 17ß-estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner. Am J Physiol Lung Cell Mol Physiol. 2019 Sep 25; PMID: 31553636; PMCID: PMC6879909

Fuentes N, Cabello N, Mishra V, Nicoleau M, Silveyra P. Modulation of the lung inflammatory response to ozone by the estrous cycle. Physiol Rep. 2019 Mar;7(5):e14026. PMID: 30848106; PMCID: PMC6405886

Fuentes, N., Silveyra, P. Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice. J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58664. PMID: 30663642; PMCID: PMC6428684

Fuentes N, Silveyra P. Endocrine regulation of lung disease and inflammation. Exp Biol Med (Maywood). 2018 Dec 3; PubMed PMID: 30509139. PMCID: PMC6348592

Fuentes N, Roy A, Mishra V, Cabello N, Silveyra P. Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation. Biol Sex Differ. 2018 May 8;9(1):18. PMID: 29739446; PMCID: PMC5941588

Mishra V, DiAngelo SL, Silveyra P. Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation. Biol Sex Differ. 2016;7:16. PMID: 26949510; PMCID: PMC4779258.

Cabello N, Mishra V, Sinha U, DiAngelo SL, Chroneos ZC, Ekpa NA, Cooper TK, Caruso CR, Silveyra P. Sex differences in the expression of lung inflammatory mediators in response to ozone. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1150-63. PMID: 26342085; PMCID: PMC4652152.