Doctor of Science St. Petersburg State University, St. Petersburg, Russia 2017Doctorate Degree in Veterinary Medicine College of Veterinary Medicine, University of Zurich, Switzerland 2009Ph.D. Cornell University 1971B.S. St. Francis College, Loretto, PA 1971

• 2019-Present  Chief Scientific Officer, ITMO University, St. Petersburg, Russia
• 2013-Present  Professor, Nova Southeastern University, Ft Lauderdale, Florida
• 2011-2019  Chief Scientific Officer, Theodosius Dobzhansl ky Center for Genome Bioinformatics, St. Petersburg University, St Petersbburg Russia
• 1997-2011  Sylvio Conte Senior Biomedical Research Service Fellow-NIH
• 1986-2011  Chief, Laboratory of Genomic Diversity, National Cancer Institute, NIH, Frederick, MD
• 1983-1986  Chief, Laboratory of Viral Carcinogenesis, National Cancer Institute, NIH, Frederick, MD
• 1980-2011  Chief, Section of Genetics, Laboratory of Viral Carcinogenesis, National Cancer Institute, NIH, Frederick, MD
• 1978-1980  Research Geneticist, Laboratory of Viral Carcinogenesis, National Cancer Institute, NIH, Frederick, MD. Chief-G.J. Todaro
• 1973-1978  Staff Fellow, Laboratory of Viral Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD
• 1972-1973  NIH Postdoctoral Fellow, National Cancer Institute, NIH, Bethesda, MD
• 1971-1972  Postdoctoral Fellow, genetics biochemistry, Gerontology Research Center, Baltimore

University Appointments

• 1974-Date  Adjunct Professor of Genetics, George Wash. University
• 1979-Date  Adjunct Professor, Dept. of Biology, American University
• 1982-Date  Adjunct Professor, Dept. of Zoology, University of Maryland
• 1982-1998  Adjunct Professor, Dept. of Biology, Johns Hopkins University
• 1982-Date  Adjunct Professor of Genetics, Dept. of Biology, Hood College
• 1994-Date  Adjunct Professor of Pathology, Colorado State University
• 1994-Date  Adjunct Professor, Dept. of Biology, George Mason University
• 1994-Date  Adjunct Professor, American Universityy
• 1995-Date  Adjunct Professor George Mason University
• 1994-1996  Adjunct Professor, Duke University
• 1996-Date  Director, Smithsonian Institution Training Course:"Recent Advances in Conservation Genetics"
• 1994-1996  Adjunct Professor, Dept. of Biology, Peking University
• 1997-1998  Visiting Fellow, Merton College, Oxford University
• 1998-2002  Andrew Dixon White Professor-at-Large, Cornell University
• 2004-Date  Adjunct Professor, Harvard School of Public Health
• 2005-Date  Adjunct Professor Beijing Institute of Technology
• 2012-2019  Professor of Bioinformatics, St Petersburg University, Russia

O’Brien, S.J. Tears of the Cheetah and Other Tales from the Genetic Frontier, St. Martins Press, New York, 2003, pp 273

O’Brien, S.J. Menninger, J. C and Nash, W. G.: An Atlas of Mammalian Chromosomes. John Wiley & Sons Publishers, New York, NY, 2006

Graphodatsky A., Perelman, P and O’Brien, S.J. An Atlas of Mammalian Chromosomes. John Wiley & Sons Publishers, New York, NY Second Edition, 2020

O’Brien. Stephen J, 2024 Legacy of a Magic Gene -CCR5-∆32-From Discovery to Clinical Benefit in a Generation. Proc Natl. Acad. Sci. , In Press

O’Brien, S.J. and Luo, S.J., 2022. Taxonomic species recognition should be consistent. National Science Review, 9(12), p.nwad022

Yakupova, A.; Tomarovsky, A.; Totikov, A.; Beklemisheva, V.; Logacheva, M.; Perelman, P.L.; Komissarov, A.; Dobrynin, P.; Krasheninnikova, K.; Tamazian, G.; Serdyukova, N.A.; Rayko, M.; Bulyonkova, T.; Cherkasov, N.; Pylev, V.; Peterfeld, V.; Penin, A.; Balanovska, E.; Lapidus, A.; DNA Zoo Consortium; O’Brien, S.J.; Graphodatsky, A.; Koepfli, K.-P.; Kliver, S. Chromosome-Length Assembly of the Baikal Seal (Pusa sibirica) Genome Reveals a Historically Large Population Prior to Isolation in Lake Baikal. Genes 2023, 14, 619. https://doi.org/10.3390/genes14030619

Tordiffe, A.S., Jhala, Y.V., Boitani, L., Cristescu, B., Kock, R.A., Meyer, L.R., Naylor, S., O’Brien, S.J., Schmidt-Küntzel, A., Stanley Price, M.R. and van der Merwe, V., 2023. The case for the reintroduction of cheetahs to India. Nature Ecology & Evolution, pp.1-2. IN PRESS

Oleksyk, T.K., Wolfsberger, W.W., Schubelka, K., Mangul, S. and O’Brien, S.J., 2022. The Pioneer Advantage: Filling the blank spots on the map of genome diversity in Europe. GigaScience, 11

O’Brien, Stephen. (2022). A decade of GigaScience: A perspective on conservation genetics. GigaScience. 11. 10.1093/gigascience/giac055

Houck ML, Koepfli KP, Hains T, Khan R, Charter SJ, FronczekJA, Misuraca AC, Kliver S, Perelman PL, Beklemisheva V, Graphodatsky A, Luo SJ, O’Brien SJ, Lim NT, Chin JSC, Guerra V, Tamazian G, Omer A, Weisz D, Kaemmerer K, Sturgeon G, Gaspard J, Hahn A, McDonough M, Garcia-Treviño I, Gentry J, Coke RL, Janecka JE, Harrigan RJ, Tinsman J, Smith TB, Aiden EL, Dudchenko O. Chromosome-length genome assemblies and cytogenomic analyses of pangolins reveal remarkable chromosome counts and plasticity. Chromosome Res. 2023 Apr 12;31(2):13. doi: 10.1007/s10577-023-09722-y. PMID: 37043058

Thami, Prisca K. ,Wonderful Choga, Delesa D. Mulisa, Collet Dandara, Andrey K. Shevchenko, Melvin M. Leteane, Vlad Novitsky, Stephen J. O’Brien, Myron Essex, Simani Gaseitsiwe2and Emile R. Chimusa 2024. Whole Genome Rare-Variant Association Study of HIV-1 Progression in a Southern African Population 2024 Journal of human Molecular Genetics In press

Sun ,Xin. Yue-Chen Liu1, Mikhail P. Tiunov2, Dmitry O. Gimranov3, Yan Zhuang1, Yu Han1, Carlos A. Driscoll4, Yu-Hong Pang5, Chunmei Li5, Yan Pan6, Marcela Sandoval Velasco7, Shyam Gopalakrishnan7, Rui-Zheng Yang1, Bao-Guo Li8, Kun Jin9, Xiao Xu1, Olga Uphyrkina2, Yan-Yi Huang5,10,11, Xiao-Hong Wu6, M. Thomas P. Gilbert7,12, Stephen J O’Brien13,*, Nobuyuki Yamaguchi14,*, Shu-Jin Luo1,* Ancient DNA Reveals Genetic Admixture in China during Tiger Evolution Nature Evol Ecol. IN Press

Graphodatsky, A , P Perelman , SJ O’Brien . 2020 Atlas of mammalian Chromosomes Wiley

Marra, Nicholas J.; Michael J. Stanhope; Nathaniel K. Jue; Vincent P. Richards; Stephen J. O’Brien; Agostinho Antunes; and Mahmood S. Shivji. 2021. Commentary: Unbiasing Genome-Based Analyses of Selection: An Example Using Iconic Shark Species. Frontiers in Marine Science 8, (). 10.3389/fmars.2021.696523doi:10.3389/fmars.2021.696523

Sun, Xin, Yue-Chen Liu, Mikhail P Tiunov, Dmitry O Gimranov, Yan Zhuang, Yu Han, Carlos A Driscoll, Yu-Hong Pang, Chunmei Li, Yan Pan, Marcela Sandoval Velasco, Shyam Gopalakrishnan, Rui-Zheng Yang, Bao-Guo Li, Kun Jin, Xiao Xu, Olga Uphyrkina, Yan-Yi Huang, Xiao-Hong Wu, M Thomas P Gilbert, Stephen J O’Brien, Nobuyuki Yamaguchi, Shu-Jin Luo. 2022. Ancient DNA Reveals China as a Historical Genetic Melting Pot in Tiger Evolution Nature Ecol. Evol. In press

Graphodatsky, A., P. Perelman, S.J. O’Brien. 2020. An Atlas of Mammalian Chromosomes, .Second Edition. John Wiley & Sons New York, NY

O’Brien S.J. (2022) In Memoriam: Diane R. O’Brien (1945-2021): Transformative Managing Editor Journal of heredity 113(2):218-219

Ochkalova, S.; Korchagin, V.; Vergun, A.; Urin, A.; Zilov, D.; Ryakhovsky, S.; Girnyk, A.; Martirosyan, I.; Zhernakova, D.V.; Arakelyan, M.; Danielyan, F.; Kliver, S.; Brukhin,V., O’Brien, S. Komissarov, A.; Ryskov, A. First Genome of Rock Lizard Darevskia valentini Involved in Formation of Several Parthenogenetic Species. Genes 2022, 13, 1569. //doi.org/10.3390/genes13091569

Choo, S.W., Chong, J.L., Gaubert, P., Hughes, A.C., O’Brien, S., Chaber, A.L., Antunes, A., Platto, S., Sun, N.C.M., Yu, L. and Koepfli, K.P., 2022. A collective statement in support of saving pangolins. Science of the Total Environment

O’Brien, Stephen J. An Intrepid Ecological Geneticist’s Pursuit of Industrial Melanism Journal of Heredity, 2022, 113, 360-361 //doi.org/10.1093/jhered/esac013

Yu H, Xing YT, Meng H, He B, Li WJ, Qi XZ, Zhao JY, Zhuang Y, Xu X, Yamaguchi N, Driscoll CA, O’Brien, SJ, Luo SJ. Genomic evidence for the Chinese mountain cat as a wildcat conspecific (Felis silvestris bieti) and its introgression to domestic cats. Sci Adv. 2021 Jun 23;7(26):eabg0221. doi: 10.1126/sciadv.abg0221. PMID: 34162544; PMCID: PMC8221621

Beklemisheva, Violetta R. , Polina L. Perelman, Natalya A. Lemskaya, Anastasia A. Proskuryakova, Natalya A. Serdyukova, Vladimir N. Burkanov, Maksim B. Gorshunov, Oliver Ryder, Mary Thompson, Gina Lento, Stephen J. O’Brien, Alexander S. Graphodatsky. 2021 Karyotype evolution in ten pinniped species: variability of the heterochromatin versus high conservatism of the euchromatin revealed by comparative molecular cytogenetics. GENES: IN Press

Tamazian G, Dobrynin P, Zhuk A, Zhernakova DV, Perelman PL, Serdyukova NA, Graphodatsky AS, Komissarov A, Kliver S, Cherkasov N, Scott AF, Mohr DW, Koepfli KP, O’Brien SJ, Krasheninnikova K. Draft de novo genome assembly of the elusive jaguarundi, Puma yagouaroundi. J Hered. 2021 Jun 19:esab036. doi: 10.1093/jhered/esab036. Epub ahead of print. PMID: 34146095.

889 Bredemeyer, Kevin R., Andrew J. Harris, Gang Li, Nicole M. Foley, Melody Roelke-Parker, Stephen J. O’Brien, Leslie A. Lyons, Wesley C. Warren, and William J. Murphy. 2021. Ultracontinuous single haplotype genome assemblies for the domestic cat (Felis catus) and Asian leopard cat (Prionailurus bengalensis). Jour Hered. In Press