B.Eng. University of Nottingham
M.App.Sc. University of NSW, Australia
M.S. Colorado State University 1997
Ph.D. Colorado State University 2000

Grants

• 2024-2029 NIH-NINDS R01NS137276 (MPI: Kawata, Mickleborough, & Newman. 5 year. $2,989,995 ). A mechanistic clinical trial of omega-3 fatty acids to prevent subconcussive neural injury.
• 2024-2026. U.S. Department of Defense. Air Force Research Laboratory. Aerospace Physiology Research Section. (PI: Johnson, B.D. Co-I: Mickleborough, T.D. 2 year. $334,315).  Effect of respiratory muscle training on aircrew breathing system tolerability and cognitive performance.
• 2023-2024. IU Faculty Research Support Program. (PI: Mickleborough, T.D. 1.5 year. $29,091). Omega-3 fatty acid modulation of brown adipose tissue for Arctic resilience. 
  

Scholarly Interest

My main research focus is integrative (whole-body) human exercise physiology; in particular the interactions between the respiratory and cardiovascular systems in health and disease, with emphasis on intervention studies in healthy trained/untrained individuals, the pathophysiology of respiratory disorders in athletes such as asthma and expiratory flow limitation, and the potential cardiorespiratory limitations to exercise tolerance and performance.  Research related to respiratory muscle function is directed at the respiratory system determinants of fatigue in health and disease and encompasses respiratory and circulatory mechanics, neurophysiology, muscle physiology, perception of effort and biochemistry. As a cardiopulmonary physiologist who has researched  the role of omega-3 fatty acids in airway disease and skeletal muscle health, I have a strong interest in the beneficial outcomes of omega-3 fatty acids on human health, and in particular the neuroprotective effect of omega-3 fatty acids against subconcussive head impacts.

Barenie, M.J., Escalera, A., Carter, S.J., Grange, H., Paris, H., Krinsky, D., Sogard, A.S., Schlader, Z.J. Fly, A.D. and Mickleborough, T.D. (2024). Grass-fed and non-grass-fed whey protein consumption do not attenuate exercise-induced muscle damage and soreness in resistance-trained individuals: a randomized, placebo-controlled trial. Journal of Dietary Supplements. 21 (3): 344-373.

Nowak, M.K., Kronenberger, W.G., Rettke, D., Ogbeide, O.S., Klemsz, L/M., Quinn, P.D., Mickleborough, T.D., Newman, S.D and Kawata, K. (2023). Neuro-ophthalmologic and blood biomarker responses in ADHD following subconcussive head impacts: a case-control intervention study. Frontiers in Psychiatry.  14: 1230463. doi: 10.3389/fpsyt.2023.1230463.

Sogard, A.S. and Mickleborough, T.D. (2023). The therapeutic role of inspiratory muscle training in the management of asthma: a narrative review. (2023). American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 325 (5): R645-R663.

Barenie, M.J., Freemas, J.A., Baranauskas, M.N., Goss, C.S., Freeman, K.L., Chen, X., Dickinson, S.L., Fly, A.D., Kawata, K., Chapman, R.F and Mickleborough, T.D. (2022). Effectiveness of a combined New Zealand green lipped mussel and Antarctic krill oil supplement on markers of exercise-induced muscle damage and inflammation in untrained men. Journal of Dietary Supplements. 19 (2): 184-211.

Shei, R-J., Paris, H.L., Sogard, A.S and Mickleborough, T.D. (2022). Time to Move Beyond a 'One-Size Fits All' Approach to Inspiratory Muscle Training.  Frontiers in Physiology. 12:766346. doi: 10.3389/fphys.2021.766346

Fulton, T., Baranauskas, M.N., Paris, H.L., Mickleborough, T.D., Koceja, D.M. and Chapman, R, F. (2020). Respiratory muscle fatigue alters cycling performance and locomotor muscle fatigue. Medicine & Science in Sports & Exercise. 52 (11): 2380-2389.

Nowak, M.K., Bevilacqua, Z.W., Ejima, K., Huibregtse, M., Chen, Z., Mickleborough, T.D., Newman, S. and Kawata, K.  (2020). Neuro-ophthalmologic vulnerability to repetitive subconcussive head impacts. JAMA Ophthalmology. 138 (4): 350-357. 

Paris, H.L., Fulton, T.J., Chapman, R.F., Fly, A.D. and Mickleborough, T.D. (2019). Effect of carbohydrate ingestion on central fatigue during prolonged running exercise in moderate hypoxia. Journal of Applied Physiology. 126 (1): 141-151.

Fulton, T.J., Paris, H.L., Stickford, A.S.L., Gruber, A.H., Mickleborough, T.D. and Chapman, R.F. (2018).  Locomotor-respiratory coupling is maintained in simulated moderate altitude in trained distance runners. Journal of Applied Physiology. 125 (1): 1-7. 

Shei, R.J., Chapman, R.F., Gruber, A.H. and Mickleborough, T.D. (2018). Inspiratory muscle training improves exercise capacity with thoracic load carriage. Physiological Reports. 6 (3): e13558. PMID: 29424007.

Turner, L.A., Tecklenburg-Lund, S., Chapman, R.F., Shei, R-J., Wilhite, D.P. and Mickleborough, T.D. (2016). The effect of inspiratory muscle training on respiratory and limb muscle deoxygenation during exercise with resistive inspiratory loading. International Journal of Sports Medicine. 37 (8): 598-606.

Shei, R-J., Chapman, R.F., Raglin, J.S., Thompson, K.G. and Mickleborough, T.D. (2016). Using deception to establish a reproducible improvement in 4 km cycling time trial performance. International Journal of Sports Medicine.37 (5): 341-346.

Mickleborough, T.D., Sinex, J.A., Platt, D., Chapman, R.F. and Hirt, M. (2015). The effects of PCSO-524, a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: a randomized, placebo-controlled trial. Journal of the International Society of Sports Nutrition.  12 (10).

Turner, L.A., Tecklenburg-Lund, S., Chapman, R.F., Stager, J.M., Duke J.W. and Mickleborough, T.D. (2013). Effect of inspiratory loading on limb locomotor and respiratory muscle deoxygenation during cycling exercise. Respiratory Physiology & Neurobiology. 185: 506-514

Mickleborough, T.D. Omega-3 polyunsaturated fatty acids in physical performance optimization. (2013). International Journal of Sport Nutrition & Exercise Metabolism. 23 (1): 83-96

Mickleborough, T.D., Vaughn, C.L., Shei, R-J., Davis, E.M. and Wilhite, D.P. (2013). Marine Lipid fraction PCSO-254 (Lyprinol/Omega-XL) of the New Zealand Green Lipped Mussel attenuates hyperpnea-induced bronchoconstriction in asthma. Respiratory Medicine. 107 (8): 1152-1163

Turner, L.A., Tecklenburg-Lund, S., Chapman, R.F., Stager, J.M., Wilhite, D.P. and Mickleborough, T.D. (2012). Inspiratory muscle training lowers the oxygen cost of voluntary hyperpnea. Journal of Applied Physiology. 112 (1): 127-134

Turner, L.A., Mickleborough, T.D., McConnell, A.K., Stager, J.M., Tecklenburg-Lund, S. and Lindley, M.R. (2011). Effect of inspiratory muscle training on exercise tolerance in asthmatic individuals. Medicine & Science in Sports & Exercise. 43 (11): 2031-2038.

Tecklenburg-Lund, S., Mickleborough, T.D., Turner, L.R., Fly, A.D., Stager, J.M. and Montgomery, G.S. (2010). Randomized control trial of fish oil and montelukast and their combination on airway inflammation and hyperpnea-induced bronchoconstriction in asthma. PLoS ONE. 5 (10): e13487.